Adipotide HKPao CAS NO.859216-15-2

ProName:Adipotide HKPao

CasNo:859216-15-2

Molecular Formula:C111H206N36O28S2

Appearance:white or off-white powder

Application:Adipotide is used as API medicine

DeliveryTime:Within 2-3 business days after payment

PackAge:Boxed/bagged/barreled/customized

Port:Any port of China

ProductionCapacity:5000 Kilogram/Month

Purity:99%

Storage:Sealed dry storage

Transportation:Express, Air, Sea

LimitNum:1 Gram

Description

What is the function ofAlCAR transformylase?

AlCAR transformylase, also known as AICARFT (AlCAR transformylase/lMP cyclohydrolase), is an enzyme involved in the purinebiosynthesis pathway. t plays a crucial role in converting 5-Aminoimidazole-4-carboxamide ribonucleotide (AlCAR) to inosine

monophosphate (lMP), an essential precursor for the synthesis of purine nucleotides

AlCAR transformylase catalyzes the addition of a formyl group to AlCAR, resulting in the formation of N-formyAICAR (NFAICAR)

This step is important for the subsequent reactions in the pathway.After the transformylation step, AlCAR transformylase also possesses cyclohydrolase activity. lt converts NFAICAR into lMP byremoving the formyl group and rearranging the molecule.

The production of lMP is a critical step in the purine biosynthesis pathway, as it serves as a precursor for the synthesis of adenineand guanine nucleotides, which are essential components of DNA, RNA, and ATP (adenosine triphosphate)Deficiencies or dysfunctions in AlCAR transformylase can lead to metabolic disorders, specifically in the purine metabolism pathway,resulting in diseases such as AlCAR transformylasel/lMP cyclohydrolase deficiency (ATlc deficiency). These conditions arecharacterized by abnormalities in the levels of purine nucleotides, leading to neurological symptoms and developmental delays.

What is the mechanism of action of AlCAR?

The mechanism of action of AlCAR (5-Aminoimidazole-4-carboxamide ribonucleotide) primarily involves activation of the

enzyme AMP-activated protein kinase (AMPK)

AlCAR is taken up by cells and converted into its active fom, ZMP (5-Aminoimidazole-4-carboxamide ribonucleotide

monophosphate). ZMP mimics the efects of AMP (adenosine monophosphate), a cellular energy sensor, and allosterically activates

AMPK.

Once activated, AlMPK phosphorylates various downstream targets, leading to a wide range of metabolic efects. it acts as a masterregulator of cellular energy homeostasis and helps maintain energy balance.

AMPK activation by AlCAR has several effects on energy metabolism, including.Enhanced glucose uptake: AlMPK activation promotes the translocation of glucose transporters (such as GLUT4) to the cell suriace.increasing glucose uptake by cells, particularly in skeletal muscles. This helps to increase cellular energy productionIncreased fatty acid oxidation. AlCAR-activated AMPK stimulates fatty acid oxidation, allowing cells to utlize stored fats as an energy

source.

Suppression of energy-consuming processes: AMPK activation inhibits energy-consuming processes such as protein synthesis, fattyacid synthesis, and cholesterol synthesis. This helps to conserve energy during times of cellular stress or energy deficitMitochondrial biogenesis. AlCAR-induced AlMPK activation promotes the production and functioning of mitochondra. the cellular

powerhouses responsible for energy production.

The activation of AMPK by AlCAR leads to phvsiological changes similar to those seen during exercise, such as increased glucoseuptake, enhanced fatty acid oxidation, and improved endurance capacity in skeletal muscles.